LGG  Firebrowse (January 28, 2016)


Dataset at a glance

No. Samples516
No. mutated genes14102
No. SNVs30549
No. CNAs1956

Most Mutated Genes


Gene
Mutated
Samples

SNVs
Inactivating
SNVs

CNAs
View MutationsView Annotations
IDH140140100>>>>
TP53250250540>>>>
ATRX21419816921>>>>
CIC108108500>>>>
CDKN2A823180>>>>
C11orf58810081>>>>
TTN707000>>>>
TFPT592157>>>>
EGFR5435338>>>>
PIK3CA534409>>>>
ING5511050>>>>
FUBP14747440>>>>
EXT1462044>>>>
PTPRD454141>>>>
MYC450045>>>>
NDRG1420042>>>>
NOTCH1424280>>>>
FGFR2422040>>>>
MUC16424210>>>>
LINC00536420042>>>>
GPHN391038>>>>
TSHR373034>>>>
PARP11361035>>>>
RAD51B360036>>>>
KIAA1549355030>>>>
LINC00290350035>>>>
BRAF345029>>>>
NF13333250>>>>
MET327226>>>>
TRIP11322030>>>>
SMO311030>>>>
CREB3L2301029>>>>
RANBP17303127>>>>
SETD23010620>>>>
EZH2302028>>>>
CDK4291028>>>>
FLG292900>>>>
RB1296524>>>>
EBF1281027>>>>
MUC17282820>>>>
PDGFRA2810422>>>>
DPP6281027>>>>
ITK271026>>>>
TLX3271026>>>>
NPM1271126>>>>
ARID22611716>>>>
SMARCA4262600>>>>
TFRC252023>>>>
PTPRN2240024>>>>
ROS12411313>>>>
PTEN232370>>>>
FIP1L1232222>>>>
RYR2232310>>>>
ARHGEF12223119>>>>
PIK3R1222270>>>>
PBRM1226517>>>>
DDX5215216>>>>
CDKN2C213218>>>>
ZBTB20212130>>>>
PRKAR1A202018>>>>
TERT203017>>>>
IDH2202000>>>>
ARID1A2020170>>>>
ECT2L193116>>>>
CANT1194015>>>>
FAM47C191900>>>>
BPTF193016>>>>
CBL191018>>>>
SRSF2181017>>>>
PARK2181117>>>>
MDM4181017>>>>
HMCN1181820>>>>
NIPBL1818140>>>>
ASPSCR1171016>>>>
TNFAIP3172015>>>>
BAP1170017>>>>
LRP2171710>>>>
OBSCN161630>>>>
APOB161620>>>>
CD79B160016>>>>
RFNG160016>>>>
MYH4161630>>>>
GOPC162014>>>>
HDAC2164312>>>>
CSMD3151510>>>>
PCLO151500>>>>
BCOR1515100>>>>
MYB151014>>>>
TCF121515140>>>>
CBX8150015>>>>
MYH2151500>>>>
ZNF2921414100>>>>
MYH8141420>>>>
KMT2C141420>>>>
MSN141013>>>>
NTRK1132011>>>>
GPR98131310>>>>
EZR130013>>>>
ANKRD30A131320>>>>
FAT2131310>>>>

Mutations plot


Most Mutated Pathways

Gene SetNo. GenesDatabaseMutated Samples SNVsInactivating SNVsCNAsTop 5 Genes
Pathways in cancer - Homo sapiens (human)329KEGG441927156412View
Glutathione metabolism - Homo sapiens (human)50KEGG42646170View
Citrate cycle (TCA cycle) - Homo sapiens (human)31KEGG42445740View
MAPK signaling pathway - Homo sapiens (human)269KEGG397706139185View
Glioma - Homo sapiens (human)65KEGG39149793230View
Melanoma - Homo sapiens (human)71KEGG38848191256View
Prostate cancer - Homo sapiens (human)89KEGG386515101191View
Chronic myeloid leukemia - Homo sapiens (human)75KEGG38343686245View
Non-small cell lung cancer - Homo sapiens (human)54KEGG37944182208View
Pancreatic cancer - Homo sapiens (human)72KEGG37545784208View
Colorectal cancer - Homo sapiens (human)84KEGG37148492169View
Endometrial cancer - Homo sapiens (human)52KEGG37144985121View
Cell cycle - Homo sapiens (human)125KEGG35843492207View
Small cell lung cancer - Homo sapiens (human)86KEGG35850493106View
Neurotrophin signaling pathway - Homo sapiens (human)126KEGG3554878449View
Bladder cancer - Homo sapiens (human)42KEGG34635872244View
p53 signaling pathway - Homo sapiens (human)68KEGG33036177125View
Apoptosis - Homo sapiens (human)87KEGG3263997438View
Huntington's disease - Homo sapiens (human)179KEGG3174248041View
Focal adhesion - Homo sapiens (human)199KEGG31255676124View