LAML  Firebrowse (January 28, 2016)


Dataset at a glance

No. Samples193
No. mutated genes6625
No. SNVs1731
No. CNAs127

Most Mutated Genes


Gene
Mutated
Samples

SNVs
Inactivating
SNVs

CNAs
View MutationsView Annotations
FLT3525270>>>>
DNMT3A4848130>>>>
NPM13333320>>>>
IDH2202000>>>>
IDH1181800>>>>
TET21717170>>>>
RUNX1161690>>>>
NRAS151500>>>>
TP53141470>>>>
CD74132011>>>>
CEBPA131390>>>>
PDGFRB121011>>>>
WT11212100>>>>
PTPN119900>>>>
EZH29326>>>>
U2AF18800>>>>
KIT8810>>>>
KRAS8800>>>>
ETV68216>>>>
SMC37720>>>>
ERG7007>>>>
CBFB7225>>>>
NF17217>>>>
SMO6006>>>>
CDKN1B6006>>>>
TTN6600>>>>
PHF66640>>>>
SMC1A6610>>>>
STAG26660>>>>
WWOX6006>>>>
KIAA15495005>>>>
BRAF5005>>>>
CREB3L25005>>>>
BRINP35500>>>>
ASXL15550>>>>
FOXP15005>>>>
RAD215550>>>>
CDH14004>>>>
MITF4004>>>>
PLCE14400>>>>
MUC163300>>>>
MAF3003>>>>
SMG13300>>>>
DNAH93300>>>>
CSMD13310>>>>
FANCA3003>>>>
KDM6A3310>>>>
CACNA1B3300>>>>
CACNA1E3300>>>>
CBFA2T33003>>>>
SPEN3310>>>>
GBP43300>>>>
COL12A13300>>>>
SUZ123310>>>>
FCGBP3300>>>>
TERF23003>>>>
PTPRT3300>>>>
DIS33300>>>>
OR13H12200>>>>
SEMA4A2210>>>>
MTUS22200>>>>
GATA22200>>>>
R3HCC1L2200>>>>
DDX412210>>>>
GPR1122200>>>>
SETBP12200>>>>
PKHD1L12200>>>>
APOB2200>>>>
SI2200>>>>
GRM82200>>>>
OR11H122200>>>>
KIF2B2200>>>>
NRXN32200>>>>
KCNK132210>>>>
PPP1R3A2200>>>>
CBL2210>>>>
GIGYF22220>>>>
BSN2200>>>>
FAM57B2210>>>>
GRID12210>>>>
SCAF82200>>>>
EGFR2200>>>>
GJB32210>>>>
RBBP42200>>>>
NMUR22200>>>>
CALR2220>>>>
E2F82210>>>>
SCN1A2200>>>>
FRYL2210>>>>
PRPF82200>>>>
TRPM32200>>>>
TUBA3C2200>>>>
PLEKHH12200>>>>
MTMR82200>>>>
CRISPLD12200>>>>
CNTN52200>>>>
ZC3H182210>>>>
KDM3B2210>>>>
CSMD32200>>>>
CADM22200>>>>

Mutations plot


Most Mutated Pathways

Gene SetNo. GenesDatabaseMutated Samples SNVsInactivating SNVsCNAsTop 5 Genes
Pathways in cancer - Homo sapiens (human)329KEGG1291543836View
Acute myeloid leukemia - Homo sapiens (human)57KEGG105117275View
Cytokine-cytokine receptor interaction - Homo sapiens (human)262KEGG8377811View
Chronic myeloid leukemia - Homo sapiens (human)75KEGG67711711View
MAPK signaling pathway - Homo sapiens (human)269KEGG64691023View
Hematopoietic cell lineage - Homo sapiens (human)87KEGG636480View
Neurotrophin signaling pathway - Homo sapiens (human)126KEGG565775View
Cysteine and methionine metabolism - Homo sapiens (human)34KEGG5051130View
Melanoma - Homo sapiens (human)71KEGG4944724View
Prostate cancer - Homo sapiens (human)89KEGG4845727View
Cell cycle - Homo sapiens (human)125KEGG4748216View
Regulation of actin cytoskeleton - Homo sapiens (human)213KEGG4743316View
Gap junction - Homo sapiens (human)90KEGG4640011View
Endometrial cancer - Homo sapiens (human)52KEGG464479View
Glioma - Homo sapiens (human)65KEGG4646716View
Bladder cancer - Homo sapiens (human)42KEGG454279View
Thyroid cancer - Homo sapiens (human)29KEGG443979View
Melanogenesis - Homo sapiens (human)101KEGG433819View
Non-small cell lung cancer - Homo sapiens (human)54KEGG434375View
Glutathione metabolism - Homo sapiens (human)50KEGG414300View