GBM  Firebrowse (January 28, 2016)


Dataset at a glance

No. Samples283
No. mutated genes11147
No. SNVs14948
No. CNAs1523

Most Mutated Genes


Gene
Mutated
Samples

SNVs
Inactivating
SNVs

CNAs
View MutationsView Annotations
CDKN2A17722176>>>>
PTEN114864031>>>>
TP5384791513>>>>
EGFR747400>>>>
TTN717100>>>>
RPL22640064>>>>
CDK4520052>>>>
PDGFRA4311039>>>>
MUC16434330>>>>
RB141242328>>>>
MDM4401039>>>>
NF139292516>>>>
FIP1L1381037>>>>
PIK3R13232100>>>>
FLG313130>>>>
MDM2302128>>>>
RYR2282800>>>>
PIK3CA272730>>>>
LRP1B257119>>>>
CDKN2C253324>>>>
ROS1254221>>>>
PCLO242440>>>>
SPTA1242430>>>>
NPAS3240024>>>>
MUC17222200>>>>
GOPC221021>>>>
ECT2L211020>>>>
BUB1B210021>>>>
MYB211020>>>>
TNFAIP3200020>>>>
LINC00290200020>>>>
SOX2200020>>>>
SMYD3192117>>>>
HMCN1191930>>>>
PAOX191018>>>>
AHNAK2181810>>>>
RYR3171740>>>>
OBSCN161620>>>>
ATRX1616100>>>>
KEL151530>>>>
FGFR3153112>>>>
LRP2151520>>>>
USH2A151500>>>>
PKHD1151510>>>>
HDAC2153112>>>>
GPR98141410>>>>
APOB141430>>>>
CDKN1B141013>>>>
TFRC140014>>>>
DNAH5141410>>>>
TCHH141400>>>>
CCND2142113>>>>
FRAS1141410>>>>
IDH1141400>>>>
PHRF113409>>>>
PALB2130013>>>>
RELN131330>>>>
COL6A3131330>>>>
DNAH2131320>>>>
CNTNAP2131300>>>>
SYNE1131310>>>>
SDK1121200>>>>
H3F3A120012>>>>
GPHN120012>>>>
ARID2122110>>>>
DSP121210>>>>
DNAH8121220>>>>
NLRP5121200>>>>
STAG21212100>>>>
BCL11B12418>>>>
DMD111100>>>>
MROH2B111110>>>>
HCN1111120>>>>
FBN3111100>>>>
HRNR111110>>>>
SEMA3C111110>>>>
GABRA6111100>>>>
SCN9A111100>>>>
COL1A2111100>>>>
DNAH3111100>>>>
CDH18111110>>>>
RAD51B110011>>>>
LETM1111111>>>>
ABCC9111120>>>>
CHD9101000>>>>
SPAG17101000>>>>
FAT2101010>>>>
DOCK5101000>>>>
SIRT310109>>>>
KMT2C101000>>>>
DICER110406>>>>
FLG2101020>>>>
FCGBP101010>>>>
ABCB1101010>>>>
RIMS2101030>>>>
LZTR1101000>>>>
DNAH11101000>>>>
ETV6100010>>>>
CHD89960>>>>
GRIN2A9900>>>>

Mutations plot


Most Mutated Pathways

Gene SetNo. GenesDatabaseMutated Samples SNVsInactivating SNVsCNAsTop 5 Genes
Pathways in cancer - Homo sapiens (human)329KEGG275670131436View
Glioma - Homo sapiens (human)65KEGG269408100388View
Melanoma - Homo sapiens (human)71KEGG26939299395View
Bladder cancer - Homo sapiens (human)42KEGG26521646318View
Non-small cell lung cancer - Homo sapiens (human)54KEGG26529959290View
p53 signaling pathway - Homo sapiens (human)68KEGG26421264364View
Pancreatic cancer - Homo sapiens (human)72KEGG26330762281View
Cell cycle - Homo sapiens (human)125KEGG26221870392View
Chronic myeloid leukemia - Homo sapiens (human)75KEGG26123359343View
Focal adhesion - Homo sapiens (human)199KEGG25354086103View
Small cell lung cancer - Homo sapiens (human)86KEGG249365101153View
Prostate cancer - Homo sapiens (human)89KEGG246423103177View
Endometrial cancer - Homo sapiens (human)52KEGG2283547257View
MAPK signaling pathway - Homo sapiens (human)269KEGG2264166493View
Olfactory transduction - Homo sapiens (human)389KEGG224483330View
Regulation of actin cytoskeleton - Homo sapiens (human)213KEGG2203433460View
Calcium signaling pathway - Homo sapiens (human)177KEGG2083372139View
Colorectal cancer - Homo sapiens (human)84KEGG2073063463View
Tight junction - Homo sapiens (human)132KEGG2022255396View
Phosphatidylinositol signaling system - Homo sapiens (human)76KEGG1942566731View