ESCA  Firebrowse (January 28, 2016)


Dataset at a glance

No. Samples185
No. mutated genes14722
No. SNVs35687
No. CNAs1393

Most Mutated Genes


Gene
Mutated
Samples

SNVs
Inactivating
SNVs

CNAs
View MutationsView Annotations
TP53153153570>>>>
CDKN2A9917883>>>>
TTN959500>>>>
LRP1B8733460>>>>
FGF3772075>>>>
TERC670067>>>>
MYC670067>>>>
MUC16515170>>>>
CDK6472045>>>>
SYNE1444430>>>>
ERBB24211036>>>>
SMAD43913527>>>>
CSMD3393940>>>>
VEGFA370037>>>>
PARD3B365033>>>>
DNAH5353530>>>>
HMCN1333370>>>>
FLG323220>>>>
EGFR325028>>>>
ARID1A32151219>>>>
KMT2D3131140>>>>
RYR2313160>>>>
USH2A292930>>>>
KAT6A299020>>>>
PCLO292980>>>>
PARK2283125>>>>
KDM6A288321>>>>
CSMD1272770>>>>
PARD3277421>>>>
KRAS273024>>>>
STK11275323>>>>
TRIM33263023>>>>
PKHD1L1262640>>>>
SPTA1252520>>>>
FAT3252540>>>>
FAT4252540>>>>
CARS245020>>>>
OBSCN242440>>>>
PTEN247318>>>>
NRAS241023>>>>
ANKS1B237017>>>>
DYNC2H1232360>>>>
XIRP2232320>>>>
FSTL3231022>>>>
CCNE1232121>>>>
TCF3232121>>>>
RYR3232350>>>>
GPR98222220>>>>
IKBKB222021>>>>
RB1227615>>>>
ATM212130>>>>
DST212130>>>>
PCDH15212120>>>>
EYS212130>>>>
ZNF804B212110>>>>
NEB202030>>>>
COL11A1202040>>>>
SIRT3202018>>>>
LRRK2202030>>>>
MUC17202000>>>>
UNC13C202020>>>>
NBEA202010>>>>
SYNE2202020>>>>
DMD191930>>>>
PHRF1191118>>>>
CNTNAP5191910>>>>
PTPRD191900>>>>
PIK3CA191900>>>>
ZFHX4191910>>>>
FMN2191920>>>>
DNAH3191940>>>>
HRAS191018>>>>
DNAH10191930>>>>
APOB181840>>>>
NOTCH11818110>>>>
COL6A5181820>>>>
MUC5B181820>>>>
LAMA1181820>>>>
HUWE1181810>>>>
LRP2181810>>>>
TENM4181800>>>>
FSIP2171760>>>>
ERBB4171740>>>>
BCL2170017>>>>
ABCA13171730>>>>
DOCK2171730>>>>
NAV3171720>>>>
RELN171710>>>>
SACS171710>>>>
MED12L171720>>>>
MYO18B171730>>>>
DNAH7171740>>>>
DNAH9171740>>>>
MDN1171730>>>>
RIMS2171730>>>>
DCHS2171720>>>>
HYDIN161620>>>>
LRRIQ1161640>>>>
KCNIP4160016>>>>
BAI3161600>>>>

Mutations plot


Most Mutated Pathways

Gene SetNo. GenesDatabaseMutated Samples SNVsInactivating SNVsCNAsTop 5 Genes
Pathways in cancer - Homo sapiens (human)329KEGG1841001209555View
MAPK signaling pathway - Homo sapiens (human)269KEGG182691156256View
Pancreatic cancer - Homo sapiens (human)72KEGG181362101316View
Chronic myeloid leukemia - Homo sapiens (human)75KEGG18135397323View
Cell cycle - Homo sapiens (human)125KEGG179428130258View
Wnt signaling pathway - Homo sapiens (human)150KEGG17946611094View
Prostate cancer - Homo sapiens (human)89KEGG179385103221View
Focal adhesion - Homo sapiens (human)199KEGG17868994154View
Regulation of actin cytoskeleton - Homo sapiens (human)213KEGG17853064168View
Colorectal cancer - Homo sapiens (human)84KEGG178386101163View
Glioma - Homo sapiens (human)65KEGG17833188254View
Melanoma - Homo sapiens (human)71KEGG17832792329View
Neurotrophin signaling pathway - Homo sapiens (human)126KEGG17738287103View
Endometrial cancer - Homo sapiens (human)52KEGG17731984214View
Small cell lung cancer - Homo sapiens (human)86KEGG17740199204View
Non-small cell lung cancer - Homo sapiens (human)54KEGG17730583272View
Bladder cancer - Homo sapiens (human)42KEGG17625783331View
p53 signaling pathway - Homo sapiens (human)68KEGG17528292167View
Apoptosis - Homo sapiens (human)87KEGG1723057838View
Neuroactive ligand-receptor interaction - Homo sapiens (human)256KEGG1715357021View