BRCA  Firebrowse (January 28, 2016)


Dataset at a glance

No. Samples977
No. mutated genes16240
No. SNVs58065
No. CNAs6441

Most Mutated Genes


Gene
Mutated
Samples

SNVs
Inactivating
SNVs

CNAs
View MutationsView Annotations
PIK3CA3963162123>>>>
TP532952951180>>>>
CCND124310242>>>>
MYC22210221>>>>
TUBD119630194>>>>
MCL117510174>>>>
ERBB2162200146>>>>
PCSK716053156>>>>
SMYD315751152>>>>
SDHD15700157>>>>
PAFAH1B215600156>>>>
TTN15415400>>>>
POU2AF115100151>>>>
CSMD1141255119>>>>
FH14021138>>>>
INTS413841134>>>>
ZNF21713681130>>>>
SDHB13620134>>>>
PAX713510134>>>>
PTEN1293521101>>>>
TCF312621124>>>>
IKBKB12152116>>>>
RB1111191797>>>>
CDH1105105880>>>>
MLLT410416590>>>>
BRCA19813486>>>>
GATA39797910>>>>
IGF1R956190>>>>
SIRT3943091>>>>
HRAS922090>>>>
FAT19123369>>>>
ETV4850085>>>>
PTPRD8317367>>>>
ANKS1B826276>>>>
ING5821081>>>>
MAP2K480322050>>>>
RAD51B793076>>>>
RBM15795175>>>>
PDE4D788070>>>>
PIK3R17714164>>>>
BCL7A750075>>>>
KDM5A756170>>>>
CDKN2A741173>>>>
MUC16747450>>>>
GPHN725267>>>>
ING1714067>>>>
BCL10703067>>>>
MAP3K17070580>>>>
KMT2C6969480>>>>
ERCC5695064>>>>
LINC00290660066>>>>
CDKN1B66101056>>>>
IL6ST647259>>>>
CCNE1642062>>>>
TRIM33625258>>>>
NRAS612059>>>>
COX18610061>>>>
MEN1612159>>>>
FANCA607153>>>>
SUV420H2592157>>>>
CBFA2T3531052>>>>
USH2A454520>>>>
FLG454530>>>>
SYNE1424250>>>>
RYR2414130>>>>
NCOR14040220>>>>
DMD383880>>>>
HMCN1373750>>>>
RYR3373780>>>>
NEB3636100>>>>
FAT3353560>>>>
SYNE2353540>>>>
SPTA1333330>>>>
MUC5B333360>>>>
HUWE1333320>>>>
SPEN3232210>>>>
APOB313130>>>>
ZFHX4313120>>>>
MUC17313140>>>>
MDN1313150>>>>
HRNR313150>>>>
LRP2303030>>>>
RUNX12929180>>>>
PCLO292990>>>>
ABCA13282850>>>>
NF12828180>>>>
RYR1282840>>>>
TBX32727170>>>>
GPR982727100>>>>
OBSCN272770>>>>
ARID1A2727160>>>>
CACNA1E262630>>>>
FCGBP262610>>>>
DNAH17262630>>>>
HYDIN252530>>>>
XIRP2252530>>>>
MXRA5252540>>>>
LRP1252570>>>>
UBR4242420>>>>
HERC2242440>>>>

Mutations plot


Most Mutated Pathways

Gene SetNo. GenesDatabaseMutated Samples SNVsInactivating SNVsCNAsTop 5 Genes
Pathways in cancer - Homo sapiens (human)329KEGG89819844631678View
Endometrial cancer - Homo sapiens (human)52KEGG8289612601046View
Chronic myeloid leukemia - Homo sapiens (human)75KEGG8289132081141View
Prostate cancer - Homo sapiens (human)89KEGG8269812141246View
Small cell lung cancer - Homo sapiens (human)86KEGG81810552281082View
Melanoma - Homo sapiens (human)71KEGG813951269939View
Focal adhesion - Homo sapiens (human)199KEGG8091330187856View
Pancreatic cancer - Homo sapiens (human)72KEGG795886179861View
Glioma - Homo sapiens (human)65KEGG793877192939View
Non-small cell lung cancer - Homo sapiens (human)54KEGG789824168894View
Colorectal cancer - Homo sapiens (human)84KEGG779902177740View
Acute myeloid leukemia - Homo sapiens (human)57KEGG75453846915View
Neurotrophin signaling pathway - Homo sapiens (human)126KEGG7321049242452View
Jak-STAT signaling pathway - Homo sapiens (human)155KEGG72776186709View
ErbB signaling pathway - Homo sapiens (human)87KEGG72270478809View
MAPK signaling pathway - Homo sapiens (human)269KEGG7161229346536View
Bladder cancer - Homo sapiens (human)42KEGG707536240928View
Cell cycle - Homo sapiens (human)125KEGG679699228751View
Apoptosis - Homo sapiens (human)87KEGG672859166303View
Chemokine signaling pathway - Homo sapiens (human)190KEGG66983084452View