BRCA  TCGA Pan-Cancer


Dataset at a glance

No. Samples772
No. mutated genes14574
No. SNVs32786
No. CNAs3789

Most Mutated Genes


Gene
Mutated
Samples

SNVs
Inactivating
SNVs

CNAs
View MutationsView Annotations
PIK3CA277261229>>>>
TP53255255980>>>>
CCND114010139>>>>
TTN11311300>>>>
ERBB210513093>>>>
MYC991098>>>>
ZNF703830083>>>>
LINC00536830083>>>>
WHSC1L1794176>>>>
TUBD1772075>>>>
LETM2751174>>>>
INTS4681167>>>>
BPTF674063>>>>
GATA36262590>>>>
ZNF217606155>>>>
KMT2C5959310>>>>
MUC4595900>>>>
MCL1581057>>>>
IKBKB574153>>>>
KDM2A565251>>>>
MAP3K15656480>>>>
CDH15555440>>>>
POLB540054>>>>
MUC16545420>>>>
KAT6A534049>>>>
PARP10492147>>>>
CYC1470047>>>>
MUC12444460>>>>
PHF12444140>>>>
ERAL1420042>>>>
CBX8422041>>>>
MDM4413138>>>>
SMYD3413138>>>>
FH370037>>>>
MRPS28360036>>>>
USH2A363610>>>>
FLG353520>>>>
FOXA13415519>>>>
MAP2K43427157>>>>
LYZ320032>>>>
MT-ND5313130>>>>
NCOR13030210>>>>
RYR2303010>>>>
PTEN2926173>>>>
NCOA3292900>>>>
NCOR2292980>>>>
FRG1B292920>>>>
IGF1R292028>>>>
KDM5A292028>>>>
AKT1281909>>>>
ITPR12810218>>>>
KAT6B289019>>>>
SYNE1282860>>>>
CSMD1272146>>>>
HRNR272750>>>>
FAM208B269219>>>>
NBPF1262600>>>>
CCNE1261025>>>>
MDM2262024>>>>
GOLGA6L2262640>>>>
FAT3262620>>>>
DMD252540>>>>
NEB252540>>>>
SPTA1252540>>>>
HMCN1252510>>>>
MUC5B252530>>>>
MUC17252530>>>>
SOX17250025>>>>
LOC283050230023>>>>
RUNX12323150>>>>
KATNAL1232021>>>>
ZFHX4232320>>>>
LRP2232310>>>>
RYR3232350>>>>
AKR1C2224118>>>>
MUC2222200>>>>
COX18220022>>>>
SYNE2222220>>>>
EHF221021>>>>
APOB212120>>>>
MT-CO1212120>>>>
TERC210021>>>>
EYS211427>>>>
SOX2211020>>>>
BDH1201019>>>>
MLLT4201149>>>>
PIK3R1202000>>>>
PTPRN2206014>>>>
NEDD9207113>>>>
ERCC5204016>>>>
PKHD1L1202050>>>>
SUV420H2200020>>>>
ATM191663>>>>
TLN1191237>>>>
MT-ND4191920>>>>
MED12191950>>>>
RELN191920>>>>
RB11914136>>>>
CSMD2181820>>>>
KIAA2026188011>>>>

Mutations plot


Most Mutated Pathways

Gene SetNo. GenesDatabaseMutated Samples SNVsInactivating SNVsCNAsTop 5 Genes
Pathways in cancer - Homo sapiens (human)329KEGG6981367292629View
Prostate cancer - Homo sapiens (human)89KEGG632777159449View
Small cell lung cancer - Homo sapiens (human)86KEGG628819168403View
Chronic myeloid leukemia - Homo sapiens (human)75KEGG620743160421View
Endometrial cancer - Homo sapiens (human)52KEGG619747174392View
Focal adhesion - Homo sapiens (human)199KEGG61489193324View
Pancreatic cancer - Homo sapiens (human)72KEGG612712136399View
Melanoma - Homo sapiens (human)71KEGG611739185305View
Glioma - Homo sapiens (human)65KEGG602714144305View
Colorectal cancer - Homo sapiens (human)84KEGG597715122328View
Non-small cell lung cancer - Homo sapiens (human)54KEGG597675126340View
Neurotrophin signaling pathway - Homo sapiens (human)126KEGG579814181102View
Apoptosis - Homo sapiens (human)87KEGG543689124103View
Jak-STAT signaling pathway - Homo sapiens (human)155KEGG53356150284View
MAPK signaling pathway - Homo sapiens (human)269KEGG531864234198View
Acute myeloid leukemia - Homo sapiens (human)57KEGG52043931339View
ErbB signaling pathway - Homo sapiens (human)87KEGG50953646259View
Regulation of actin cytoskeleton - Homo sapiens (human)213KEGG4887085359View
Cell cycle - Homo sapiens (human)125KEGG483502165338View
Chemokine signaling pathway - Homo sapiens (human)190KEGG48059940102View